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Target
Mitogen-activated protein kinase 1
Ligand
BDBM50275657
Substrate
n/a
Meas. Tech.
ChEMBL_492772 (CHEMBL939460)
IC50
27400±n/a nM
Citation
 Park, H; Bahn, YJ; Jeong, DG; Woo, EJ; Kwon, JS; Ryu, SE Identification of novel inhibitors of extracellular signal-regulated kinase 2 based on the structure-based virtual screening. Bioorg Med Chem Lett 18:5372-6 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM50275657
Synonyms:
5-(2-fluorobenzyloxy)-2-(4-(2-methoxyphenyl)-1H-pyrazol-3-yl)phenol | CHEMBL486541
Type:
Small organic molecule
Emp. Form.:
C23H19FN2O3
Mol. Mass.:
390.407
SMILES:
COc1ccccc1-c1c[nH]nc1-c1ccc(OCc2ccccc2F)cc1O
Structure:
Search PDB for entries with ligand similarity: