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Target
Bcl2-associated agonist of cell death
Ligand
BDBM50274315
Substrate
n/a
Meas. Tech.
ChEMBL_537289 (CHEMBL985385)
Ki
14±n/a nM
Citation
 Park, CM; Bruncko, M; Adickes, J; Bauch, J; Ding, H; Kunzer, A; Marsh, KC; Nimmer, P; Shoemaker, AR; Song, X; Tahir, SK; Tse, C; Wang, X; Wendt, MD; Yang, X; Zhang, H; Fesik, SW; Rosenberg, SH; Elmore, SW Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins. J Med Chem 51:6902-15 (2008) [PubMed]  Article 
Target
Name:
Bcl2-associated agonist of cell death
Synonyms:
BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD)
Type:
PROTEIN
Mol. Mass.:
18393.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_478760
Residue:
168
Sequence:
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
  
Inhibitor
Name:
BDBM50274315
Synonyms:
(R)-4-(4-((4'-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)phenylsulfonyl)benzamide | CHEMBL508864
Type:
Small organic molecule
Emp. Form.:
C42H46ClN5O3S2
Mol. Mass.:
768.429
SMILES:
CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 |r|
Structure:
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