Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50256379
Substrate
n/a
Meas. Tech.
ChEMBL_519288 (CHEMBL947740)
Ki
0.7±n/a nM
Citation
 Kai, H; Morioka, Y; Koriyama, Y; Okamoto, K; Hasegawa, Y; Hattori, M; Koike, K; Chiba, H; Shinohara, S; Iwamoto, Y; Takahashi, K; Tanimoto, N 2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs. Bioorg Med Chem Lett 18:6444-7 (2008) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_MOUSE | Cannabinoid CB1 receptor | Cannabinoid receptor | Cnr1
Type:
Enzyme
Mol. Mass.:
52842.52
Organism:
Mus musculus (Mouse)
Description:
P47746
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50256379
Synonyms:
CHEMBL482356 | methyl 3-(4-chloronaphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate
Type:
Small organic molecule
Emp. Form.:
C21H23ClN2OS2
Mol. Mass.:
419.003
SMILES:
CSC(=S)N1CC2(CCCCC2)CO\C1=N/c1ccc(Cl)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: