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Target
Tyrosine-protein kinase CSK
Ligand
BDBM50246396
Substrate
n/a
Meas. Tech.
ChEMBL_558923 (CHEMBL1009269)
IC50
>10000±n/a nM
Citation
 Jones, CD; Andrews, DM; Barker, AJ; Blades, K; Byth, KF; Finlay, MR; Geh, C; Green, CP; Johannsen, M; Walker, M; Weir, HM Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 18:6486-9 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase CSK
Synonyms:
C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK
Type:
Tyrosine-protein kinase
Mol. Mass.:
50707.30
Organism:
Homo sapiens (Human)
Description:
P41240
Residue:
450
Sequence:
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
  
Inhibitor
Name:
BDBM50246396
Synonyms:
2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)-N-methylbenzamide | CHEMBL455428
Type:
Small organic molecule
Emp. Form.:
C19H21FN6O
Mol. Mass.:
368.408
SMILES:
CNC(=O)c1ccc(Nc2nccc(n2)-c2cnc(C)n2C(C)C)cc1F
Structure:
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