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Target
Polyphenol oxidase 2
Ligand
BDBM50245833
Substrate
n/a
Meas. Tech.
ChEMBL_559710 (CHEMBL1012868)
IC50
>3000000±n/a nM
Citation
 Yi, W; Cao, R; Wen, H; Yan, Q; Zhou, B; Wan, Y; Ma, L; Song, H Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors. Bioorg Med Chem Lett 18:6490-3 (2008) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50245833
Synonyms:
Acetic acid (2S,3R,4R,5R,6R)-4,5-diacetoxy-2-(4-formyl-phenoxy)-6-hydroxymethyl-tetrahydro-pyran-3-yl ester | CHEMBL509476
Type:
Small organic molecule
Emp. Form.:
C19H22O10
Mol. Mass.:
410.372
SMILES:
CC(=O)O[C@@H]1[C@@H](CO)O[C@@H](Oc2ccc(C=O)cc2)[C@H](OC(C)=O)[C@@H]1OC(C)=O |r|
Structure:
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