Reaction Details Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM50146453
Substrate
n/a
Meas. Tech.
ChEMBL_559710 (CHEMBL1012868)
IC50
410000±n/a nM
Citation
 Yi, W; Cao, R; Wen, H; Yan, Q; Zhou, B; Wan, Y; Ma, L; Song, H Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors. Bioorg Med Chem Lett 18:6490-3 (2008) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50146453
Synonyms:
(E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-methoxyphenyl)acrylic acid | 4-Methoxycinnamic acid | CHEMBL95770 | para-methoxycinnamic acid
Type:
Small organic molecule
Emp. Form.:
C10H10O3
Mol. Mass.:
178.1846
SMILES:
COc1ccc(\C=C\C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: