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Target
Adenosine receptor A2a
Ligand
BDBM50170140
Substrate
n/a
Meas. Tech.
ChEMBL_559970 (CHEMBL1014569)
Ki
>1000±n/a nM
Citation
 Baraldi, PG; Preti, D; Tabrizi, MA; Romagnoli, R; Saponaro, G; Baraldi, S; Botta, M; Bernardini, C; Tafi, A; Tuccinardi, T; Martinelli, A; Varani, K; Borea, PA Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists. Bioorg Med Chem 16:10281-94 (2008) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50170140
Synonyms:
1-Benzyl-7-cyclopropyl-3-propyl-1H,8H-imidazo[2,1-f]purine-2,4-dione | 1-benzyl-7-cyclopropyl-3-propyl-1H-imidazo[1,2-a]purine-2,4(3H,8H)-dione | CHEMBL364036
Type:
Small organic molecule
Emp. Form.:
C20H21N5O2
Mol. Mass.:
363.413
SMILES:
CCCn1c(=O)n(Cc2ccccc2)c2nc3[nH]c(cn3c2c1=O)C1CC1
Structure:
Search PDB for entries with ligand similarity: