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Target
Dual specificity protein phosphatase 1
Ligand
BDBM50267115
Substrate
n/a
Meas. Tech.
ChEMBL_565116 (CHEMBL965760)
IC50
17800±n/a nM
Citation
 Cao, S; Murphy, BT; Foster, C; Lazo, JS; Kingston, DG Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem 17:2276-81 (2009) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 1
Synonyms:
3ch134 | DUS1_MOUSE | Dusp1 | Mkp1 | Ptpn10 | Ptpn16
Type:
PROTEIN
Mol. Mass.:
39372.46
Organism:
Mus musculus
Description:
ChEMBL_565116
Residue:
367
Sequence:
MVMEVGILDAGGLRALLREGAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSASLDGAKRDGTLALAAGALCREARSTQVFFLQGGYEAFSASCPELCSKQSTPTGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILSFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKDAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHPTNSALNYLKSPITTSPSC
  
Inhibitor
Name:
BDBM50267115
Synonyms:
1,1-Dioxo-1,2,3,4-tetrahydro-1lambda*6*-naphtho[2,3-b][1,4]thiazine-5,10-dione | 1,1-Dioxo-1,2,3,4-tetrahydro-1lambda6-naphtho[2,3-b][1,4]thiazine-5,10-dione | CHEMBL500348
Type:
Small organic molecule
Emp. Form.:
C12H9NO4S
Mol. Mass.:
263.269
SMILES:
O=C1C2C(=NCCS2(=O)=O)C(=O)c2ccccc12 |c:3|
Structure:
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