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Target
Alkaline phosphatase, placental type
Ligand
BDBM50253982
Substrate
n/a
Meas. Tech.
ChEMBL_559238 (CHEMBL1014657)
IC50
>10000±n/a nM
Citation
 Sidique, S; Ardecky, R; Su, Y; Narisawa, S; Brown, B; Millán, JL; Sergienko, E; Cosford, ND Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). Bioorg Med Chem Lett 19:222-5 (2008) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, placental type
Synonyms:
ALPP | Alkaline phosphatase placental type | PLAP | PPB1_HUMAN
Type:
PROTEIN
Mol. Mass.:
57950.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1506090
Residue:
535
Sequence:
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
  
Inhibitor
Name:
BDBM50253982
Synonyms:
CHEMBL461194 | N-(2-hydroxyethyl)-3-(2,3,4-trichlorophenyl)-1H-pyrazole-5-carboxamide | cid_24178170
Type:
Small organic molecule
Emp. Form.:
C12H10Cl3N3O2
Mol. Mass.:
334.586
SMILES:
OCCNC(=O)c1cc(n[nH]1)-c1ccc(Cl)c(Cl)c1Cl
Structure:
Search PDB for entries with ligand similarity: