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Target
D(3) dopamine receptor
Ligand
BDBM50273341
Substrate
n/a
Meas. Tech.
ChEMBL_561955 (CHEMBL1010018)
Ki
187±n/a nM
Citation
 Brown, DA; Kharkar, PS; Parrington, I; Reith, ME; Dutta, AK Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model. J Med Chem 51:7806-19 (2008) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50273341
Synonyms:
(+/-)-cis-1-{2-[4-(2,3-Dichlorophenyl)piperazin-1-yl]ethyl}-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-8-ol | CHEMBL517014
Type:
Small organic molecule
Emp. Form.:
C25H31Cl2N3O
Mol. Mass.:
460.439
SMILES:
Oc1ccc2C[C@@H]3CCCN(CCN4CCN(CC4)c4cccc(Cl)c4Cl)[C@@H]3Cc2c1 |r|
Structure:
Search PDB for entries with ligand similarity: