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Target
Matrix metalloproteinase-16
Ligand
BDBM50241251
Substrate
n/a
Meas. Tech.
ChEMBL_561991 (CHEMBL1010054)
IC50
44±n/a nM
Citation
 Marques, SM; Nuti, E; Rossello, A; Supuran, CT; Tuccinardi, T; Martinelli, A; Santos, MA Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates. J Med Chem 51:7968-79 (2008) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-16
Synonyms:
C8orf57 | MMP-16 | MMP-X2 | MMP16 | MMP16_HUMAN | MMPX2 | MT-MMP 3 | MT3-MMP | MT3MMP | MTMMP3 | Matrix metalloproteinase 16 | Matrix metalloproteinase-16 | Membrane-type matrix metalloproteinase 3 | Membrane-type-3 matrix metalloproteinase
Type:
PROTEIN
Mol. Mass.:
69536.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_799129
Residue:
607
Sequence:
MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
  
Inhibitor
Name:
BDBM50241251
Synonyms:
2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfonyl)-amino]-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide | CHEMBL234529 | N-(4-Methoxybenzenesulfonyl)-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}aminoacetohydroxamic Acid
Type:
Small organic molecule
Emp. Form.:
C19H24N4O8S2
Mol. Mass.:
500.546
SMILES:
COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O
Structure:
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