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Target
C-C chemokine receptor type 7
Ligand
BDBM50246956
Substrate
n/a
Meas. Tech.
ChEMBL_556978 (CHEMBL958164)
IC50
>3000±n/a nM
Citation
 Thoma, G; Streiff, MB; Kovarik, J; Glickman, F; Wagner, T; Beerli, C; Zerwes, HG Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J Med Chem 51:7915-20 (2008) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 7
Synonyms:
CCR7 | CCR7_HUMAN | CMKBR7 | EBI1 | EVI1
Type:
PROTEIN
Mol. Mass.:
42885.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_338819
Residue:
378
Sequence:
MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHIRRSSMSVEAETTTTFSP
  
Inhibitor
Name:
BDBM50246956
Synonyms:
1,3-dicyclohexyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea | CHEMBL452864
Type:
Small organic molecule
Emp. Form.:
C19H30N4S2
Mol. Mass.:
378.598
SMILES:
C(S\C(NC1CCCCC1)=N/C1CCCCC1)C1=CSC2=NCCN12 |t:19,22|
Structure:
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