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Target
Secreted frizzled-related protein 1
Ligand
BDBM50246617
Substrate
n/a
Meas. Tech.
ChEMBL_557443 (CHEMBL961559)
EC50
9000±n/a nM
Citation
 Gopalsamy, A; Shi, M; Stauffer, B; Bahat, R; Billiard, J; Ponce-de-Leon, H; Seestaller-Wehr, L; Fukayama, S; Mangine, A; Moran, R; Krishnamurthy, G; Bodine, P Identification of diarylsulfone sulfonamides as secreted frizzled related protein-1 (sFRP-1) inhibitors. J Med Chem 51:7670-2 (2008) [PubMed]  Article 
Target
Name:
Secreted frizzled-related protein 1
Synonyms:
FRP | FRP1 | SARP2 | SFRP1 | SFRP1_HUMAN
Type:
PROTEIN
Mol. Mass.:
35404.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1363191
Residue:
314
Sequence:
MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK
  
Inhibitor
Name:
BDBM50246617
Synonyms:
2-Ethyl-5-(phenylsulfonyl)-N-(3-pyrrolidin-1-ylpropyl)benzenesulfonamide | CHEMBL474115
Type:
Small organic molecule
Emp. Form.:
C21H28N2O4S2
Mol. Mass.:
436.588
SMILES:
CCc1ccc(cc1S(=O)(=O)NCCCN1CCCC1)S(=O)(=O)c1ccccc1
Structure:
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