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Target
Macrophage migration inhibitory factor
Ligand
BDBM50113768
Substrate
n/a
Meas. Tech.
ChEMBL_558850 (CHEMBL1021636)
IC50
1650±n/a nM
Citation
 Cournia, Z; Leng, L; Gandavadi, S; Du, X; Bucala, R; Jorgensen, WL Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem 52:416-24 (2009) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50113768
Synonyms:
(S)-methyl 2-(4-hydroxybenzylideneamino)-3-(1H-indol-3-yl)propanoate | 2-[(4-Hydroxy-benzylidene)-amino]-3-(1H-indol-3-yl)-propionic acid methyl ester | CHEMBL78684
Type:
Small organic molecule
Emp. Form.:
C19H18N2O3
Mol. Mass.:
322.3578
SMILES:
COC(=O)[C@H](Cc1c[nH]c2ccccc12)\N=C\c1ccc(O)cc1 |r|
Structure:
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