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Target
Carbonyl reductase [NADPH] 1
Ligand
BDBM50247677
Substrate
n/a
Meas. Tech.
ChEMBL_495288 (CHEMBL1004505)
Ki
40±n/a nM
Citation
 Zimmermann, TJ; Niesen, FH; Pilka, ES; Knapp, S; Oppermann, U; Maier, ME Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. Bioorg Med Chem 17:530-6 (2009) [PubMed]  Article 
Target
Name:
Carbonyl reductase [NADPH] 1
Synonyms:
CBR | CBR1 | CBR1_HUMAN | CRN | SDR21C1
Type:
PROTEIN
Mol. Mass.:
30380.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_607770
Residue:
277
Sequence:
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
  
Inhibitor
Name:
BDBM50247677
Synonyms:
(3S,8S)-14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione | CHEMBL453375
Type:
Small organic molecule
Emp. Form.:
C19H24O5
Mol. Mass.:
332.3909
SMILES:
C[C@H]1CCCC(=O)[C@@H](C)CC\C=C\c2cc(O)cc(O)c2C(=O)O1 |r,t:11|
Structure:
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