Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50255877
Substrate
n/a
Meas. Tech.
ChEMBL_515651 (CHEMBL1029743)
Ki
0.997000±n/a nM
Citation
 Briard, E; Zoghbi, SS; Siméon, FG; Imaizumi, M; Gourley, JP; Shetty, HU; Lu, S; Fujita, M; Innis, RB; Pike, VW Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET. J Med Chem 52:688-99 (2009) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM50255877
Synonyms:
CHEMBL473435 | N-Fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline
Type:
Small organic molecule
Emp. Form.:
C23H22FNO4
Mol. Mass.:
395.4235
SMILES:
COc1ccc(OC)c(CN(C(=O)CF)c2ccccc2Oc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: