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Target
Translocator protein
Ligand
BDBM50255877
Substrate
n/a
Meas. Tech.
ChEMBL_515649 (CHEMBL1029741)
Ki
0.180000±n/a nM
Citation
 Briard, E; Zoghbi, SS; Siméon, FG; Imaizumi, M; Gourley, JP; Shetty, HU; Lu, S; Fujita, M; Innis, RB; Pike, VW Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET. J Med Chem 52:688-99 (2009) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50255877
Synonyms:
CHEMBL473435 | N-Fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline
Type:
Small organic molecule
Emp. Form.:
C23H22FNO4
Mol. Mass.:
395.4235
SMILES:
COc1ccc(OC)c(CN(C(=O)CF)c2ccccc2Oc2ccccc2)c1
Structure:
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