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Target
Delta-type opioid receptor
Ligand
BDBM50276412
Substrate
n/a
Meas. Tech.
ChEMBL_540961 (CHEMBL1030681)
IC50
3620±n/a nM
Citation
 Dockendorff, C; Jin, S; Olsen, M; Lautens, M; Coupal, M; Hodzic, L; Spear, N; Payza, K; Walpole, C; Tomaszewski, MJ Discovery of mu-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions. Bioorg Med Chem Lett 19:1228-32 (2009) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50276412
Synonyms:
(+/-)-3,4-dichloro-N-(2-methoxyethyl)-N-(2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl)benzamide | CHEMBL460832
Type:
Small organic molecule
Emp. Form.:
C30H31Cl2N3O2
Mol. Mass.:
536.492
SMILES:
COCCN(C1C(C=Cc2ccccc12)N1CCN(CC1)c1ccccc1)C(=O)c1ccc(Cl)c(Cl)c1 |c:7|
Structure:
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