Reaction Details Report a problem with these data
Target
P2X purinoceptor 5
Ligand
BDBM50257636
Substrate
n/a
Meas. Tech.
ChEMBL_565946 (CHEMBL960841)
IC50
>10000±n/a nM
Citation
 Carter, DS; Alam, M; Cai, H; Dillon, MP; Ford, AP; Gever, JR; Jahangir, A; Lin, C; Moore, AG; Wagner, PJ; Zhai, Y Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett 19:1628-31 (2009) [PubMed]  Article 
Target
Name:
P2X purinoceptor 5
Synonyms:
ATP receptor | P2RX5 | P2RX5_HUMAN | P2X5 | Purinergic receptor
Type:
PROTEIN
Mol. Mass.:
47208.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_612725
Residue:
422
Sequence:
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHRST
  
Inhibitor
Name:
BDBM50257636
Synonyms:
5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine | CHEMBL526307
Type:
Small organic molecule
Emp. Form.:
C14H17IN4O2
Mol. Mass.:
400.2149
SMILES:
COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I
Structure:
Search PDB for entries with ligand similarity: