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Target
Acyl-CoA 6-desaturase
Ligand
BDBM50257758
Substrate
n/a
Meas. Tech.
ChEMBL_562450 (CHEMBL1010953)
IC50
>30±n/a nM
Citation
 Koltun, DO; Parkhill, EQ; Vasilevich, NI; Glushkov, AI; Zilbershtein, TM; Ivanov, AV; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett 19:2048-52 (2009) [PubMed]  Article 
Target
Name:
Acyl-CoA 6-desaturase
Synonyms:
FADS2_RAT | Fads2 | Fadsd6 | Fatty acid desaturase 2
Type:
PROTEIN
Mol. Mass.:
52399.93
Organism:
Rattus norvegicus
Description:
ChEMBL_852950
Residue:
444
Sequence:
MGKGGNQGEGSTELQAPMPTFRWEEIQKHNLRTDRWLVIDRKVYNVTKWSQRHPGGHRVIGHYSGEDATDAFRAFHLDLDFVGKFLKPLLIGELAPEEPSLDRGKSSQITEDFRALKKTAEDMNLFKTNHLFFFLLLSHIIVMESIAWFILSYFGNGWIPTVITAFVLATSQAQAGWLQHDYGHLSVYKKSIWNHIVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDIKSLHVFVLGEWQPLEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIRRRDWVDLAWAISYYARFFYTYIPFYGILGALVFLNFIRFLESHWFVWVTQMNHIVMEIDLDHYRDWFSSQLAATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIVSSLKKSGELWLDAYLHK
  
Inhibitor
Name:
BDBM50257758
Synonyms:
3-(2-(4-methoxyphenyl)-3-oxo-6-(3-(trifluoromethyl)benzylamino)pyrido[2,3-b]pyrazin-4(3H)-yl)propanamide | CHEMBL521993
Type:
Small organic molecule
Emp. Form.:
C25H22F3N5O3
Mol. Mass.:
497.4691
SMILES:
COc1ccc(cc1)-c1nc2ccc(NCc3cccc(c3)C(F)(F)F)nc2n(CCC(N)=O)c1=O
Structure:
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