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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50258119
Substrate
n/a
Meas. Tech.
ChEMBL_566454 (CHEMBL958321)
EC50
940±n/a nM
Citation
 Swahn, BM; Macsari, I; Viklund, J; Ohberg, L; Sjödin, J; Neelissen, J; Lindquist, J Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides. Bioorg Med Chem Lett 19:2009-12 (2009) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50258119
Synonyms:
CHEMBL495020 | N-(2-chloro-4-(2-chloro-N-(cyclopropylmethyl)phenylsulfonamido)phenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
Type:
Small organic molecule
Emp. Form.:
C20H19Cl2F3N2O4S
Mol. Mass.:
511.342
SMILES:
CC(O)(C(=O)Nc1ccc(cc1Cl)N(CC1CC1)S(=O)(=O)c1ccccc1Cl)C(F)(F)F
Structure:
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