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Target
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Ligand
BDBM50256804
Substrate
n/a
Meas. Tech.
ChEMBL_562793 (CHEMBL1018873)
IC50
3000±n/a nM
Citation
 Reynisson, J; Court, W; O'Neill, C; Day, J; Patterson, L; McDonald, E; Workman, P; Katan, M; Eccles, SA The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg Med Chem 17:3169-76 (2009) [PubMed]  Article 
Target
Name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Synonyms:
PLCG2 | PLCG2_HUMAN | Phospholipase C-gamma-2
Type:
PROTEIN
Mol. Mass.:
147869.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_562793
Residue:
1265
Sequence:
MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSNSKFYS
  
Inhibitor
Name:
BDBM50256804
Synonyms:
3-(2,2-dimethylchroman-6-yl)-1-(4-methoxyphenylsulfonyl)-1H-pyrazole | CHEMBL473613
Type:
Small organic molecule
Emp. Form.:
C21H22N2O4S
Mol. Mass.:
398.475
SMILES:
COc1ccc(cc1)S(=O)(=O)n1ccc(n1)-c1ccc2OC(C)(C)CCc2c1
Structure:
Search PDB for entries with ligand similarity: