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Target
Cyclin-dependent kinase 2
Ligand
BDBM5530
Substrate
n/a
Meas. Tech.
ChEMBL_501549 (CHEMBL986816)
IC50
1000±n/a nM
Citation
 Lu, Y; Shi, T; Wang, Y; Yang, H; Yan, X; Luo, X; Jiang, H; Zhu, W Halogen bonding--a novel interaction for rational drug design? J Med Chem 52:2854-62 (2009) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM5530
Synonyms:
2-Anilino-6-cyclohexylmethoxypurine | 6-(cyclohexylmethoxy)-N-phenyl-9H-purin-2-amine | CHEMBL122264 | O6-Cyclohexylmethylguanine deriv. 2
Type:
Small organic molecule
Emp. Form.:
C18H21N5O
Mol. Mass.:
323.3922
SMILES:
C(Oc1nc(Nc2ccccc2)nc2nc[nH]c12)C1CCCCC1
Structure:
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