Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50249883
Substrate
n/a
Meas. Tech.
ChEMBL_498031 (CHEMBL1000234)
EC50
7000±n/a nM
Citation
 Müller, MQ; de Koning, LJ; Schmidt, A; Ihling, C; Syha, Y; Rau, O; Mechtler, K; Schubert-Zsilavecz, M; Sinz, A An innovative method to study target protein-drug interactions by mass spectrometry. J Med Chem 52:2875-9 (2009) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50249883
Synonyms:
2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)pentanoic acid | CHEMBL491950
Type:
Small organic molecule
Emp. Form.:
C17H20ClN3O2S
Mol. Mass.:
365.878
SMILES:
CCCC(Sc1nc(Cl)cc(Nc2cccc(C)c2C)n1)C(O)=O
Structure:
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