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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50258503
Substrate
n/a
Meas. Tech.
ChEMBL_499826 (CHEMBL972458)
IC50
160±n/a nM
Citation
 Gross, MF; Castle, NA; Zou, A; Wickenden, AD; Yu, W; Spear, KL Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel. Bioorg Med Chem Lett 19:3063-6 (2009) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50258503
Synonyms:
CHEMBL466019 | N-((7R,8R)-8-(4-tert-butylphenylsulfonamido)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-3-methoxybenzamide
Type:
Small organic molecule
Emp. Form.:
C28H32N2O5S
Mol. Mass.:
508.629
SMILES:
COc1cccc(c1)C(=O)Nc1ccc2CC[C@@H](O)[C@H](NS(=O)(=O)c3ccc(cc3)C(C)(C)C)c2c1 |r|
Structure:
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