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Target
Solute carrier family 2, facilitated glucose transporter member 1
Ligand
BDBM50250141
Substrate
n/a
Meas. Tech.
ChEMBL_498540 (CHEMBL973516)
IC50
32850±n/a nM
Citation
 Gynther, M; Ropponen, J; Laine, K; Leppänen, J; Haapakoski, P; Peura, L; Järvinen, T; Rautio, J Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats. J Med Chem 52:3348-53 (2009) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 1
Synonyms:
GTR1_RAT | Glut1 | Slc2a1
Type:
PROTEIN
Mol. Mass.:
53969.94
Organism:
Rattus norvegicus
Description:
ChEMBL_659928
Residue:
492
Sequence:
MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
  
Inhibitor
Name:
BDBM50250141
Synonyms:
((2R,3S,4S,5R,6R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl 2-(3-benzoylphenyl)propanoate | CHEMBL494865
Type:
Small organic molecule
Emp. Form.:
C22H24O8
Mol. Mass.:
416.4212
SMILES:
CC(C(=O)OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O)c1cccc(c1)C(=O)c1ccccc1 |r|
Structure:
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