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Target
Carboxypeptidase B
Ligand
BDBM50279380
Substrate
n/a
Meas. Tech.
ChEMBL_545943 (CHEMBL1024278)
Ki
500000±n/a nM
Citation
 Fernández, D; Torres, E; Avilés, FX; Ortuño, RM; Vendrell, J Cyclobutane-containing peptides: evaluation as novel metallocarboxypeptidase inhibitors and modelling of their mode of action. Bioorg Med Chem 17:3824-8 (2009) [PubMed]  Article 
Target
Name:
Carboxypeptidase B
Synonyms:
CBPB1_HUMAN | CPB | CPB1 | Carboxypeptidase B | PASP | PCPB | Pancreas-specific protein | Thrombin-activatable fibrinolysis (TAFI)
Type:
Enzyme
Mol. Mass.:
47367.43
Organism:
Homo sapiens (Human)
Description:
P15086
Residue:
417
Sequence:
MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY
  
Inhibitor
Name:
BDBM50279380
Synonyms:
CHEMBL453955 | methyl 2-((1R,2S)-2-(benzyloxycarbonylamino)cyclobutanecarboxamido)acetate
Type:
Small organic molecule
Emp. Form.:
C16H20N2O5
Mol. Mass.:
320.3404
SMILES:
COC(=O)CNC(=O)[C@@H]1CC[C@@H]1NC(=O)OCc1ccccc1 |r|
Structure:
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