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Target
Histone deacetylase 3
Ligand
BDBM50258685
Substrate
n/a
Meas. Tech.
ChEMBL_500546 (CHEMBL971411)
IC50
102±n/a nM
Citation
 Tapadar, S; He, R; Luchini, DN; Billadeau, DD; Kozikowski, AP Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett 19:3023-6 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50258685
Synonyms:
CHEMBL511715 | N-hydroxy-5-(5-oxo-5-(quinolin-3-ylamino)pentyl)isoxazole-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C18H18N4O4
Mol. Mass.:
354.3599
SMILES:
ONC(=O)c1cc(CCCCC(=O)Nc2cnc3ccccc3c2)on1
Structure:
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