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Target
Neuropeptide Y receptor type 5
Ligand
BDBM50249777
Substrate
n/a
Meas. Tech.
ChEMBL_498773 (CHEMBL1021965)
Ki
1.1±n/a nM
Citation
 Sato, N; Ando, M; Ishikawa, S; Jitsuoka, M; Nagai, K; Takahashi, H; Sakuraba, A; Tsuge, H; Kitazawa, H; Iwaasa, H; Mashiko, S; Gomori, A; Moriya, R; Fujino, N; Ohe, T; Ishihara, A; Kanatani, A; Fukami, T Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect. J Med Chem 52:3385-96 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50249777
Synonyms:
2-{(4S,5S)-4-(4-Fluorophenyl)-5-methyl-4-[6-(methyloxy)-3-pyridyl]-4,5-dihydro-1H-imidazol-2-yl}-4-pyridinecarbonitrile Hydrochloride | CHEMBL506163
Type:
Small organic molecule
Emp. Form.:
C22H18FN5O
Mol. Mass.:
387.4096
SMILES:
COc1ccc(cn1)[C@@]1(N=C(N[C@H]1C)c1cc(ccn1)C#N)c1ccc(F)cc1 |r,c:10|
Structure:
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