Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50279048
Substrate
n/a
Meas. Tech.
ChEMBL_545296 (CHEMBL1020742)
IC50
2881.5±n/a nM
Citation
Wu, CH; Hung, MS; Song, JS; Yeh, TK; Chou, MC; Chu, CM; Jan, JJ; Hsieh, MT; Tseng, SL; Chang, CP; Hsieh, WP; Lin, Y; Yeh, YN; Chung, WL; Kuo, CW; Lin, CY; Shy, HS; Chao, YS; Shia, KS Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice. J Med Chem 52:4496-510 (2009) [PubMed] Article
More Info.:
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
Inhibitor
Name:
BDBM50279048
Synonyms:
1-Allyl-2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazol-3-yl]-5,5-dimethyl-1,5-dihydro-imidazol-4-one | CHEMBL527108
Type:
Small organic molecule
Emp. Form.:
C24H21Cl3N4O
Mol. Mass.:
487.809
SMILES:
Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C1=NC(=O)C(C)(C)N1CC=C |t:24|