Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Lck
Ligand
BDBM4301
Substrate
n/a
Meas. Tech.
ChEBML_221641
IC50
7000±n/a nM
Citation
 BurkeJr., TR; Li, ZH; Bolen, JB; Marquez, VE Structural influences of styryl-based inhibitors on epidermal growth factor receptor and p56lck tyrosine-specific protein kinases. Bioorg Med Chem Lett 1:165-168 (1991)    Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM4301
Synonyms:
(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide | CHEMBL296407 | Tyrphostin deriv. 40 | benzylidenemalononitrile (BMN) deriv. 46
Type:
Small organic molecule
Emp. Form.:
C10H8N2O3
Mol. Mass.:
204.1821
SMILES:
NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Structure:
Search PDB for entries with ligand similarity: