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Target
Tubulin alpha-1A chain
Ligand
BDBM50280007
Substrate
n/a
Meas. Tech.
ChEBML_212054
Ki
22000±n/a nM
Citation
 Hahn, KM; Humphreys, W; Helms, AM; Hastie, SB; Macdonald, TL Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent Bioorg Med Chem Lett 1:471-476 (1991)    Article 
Target
Name:
Tubulin alpha-1A chain
Synonyms:
TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain
Type:
Protein
Mol. Mass.:
50049.25
Organism:
Sus scrofa (Pig)
Description:
P02550
Residue:
451
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
  
Inhibitor
Name:
BDBM50280007
Synonyms:
2-Methylsulfanyl-5-(2,3,4-trimethoxy-phenyl)-cyclohepta-2,4,6-trienone | CHEMBL357071
Type:
Small organic molecule
Emp. Form.:
C17H18O4S
Mol. Mass.:
318.387
SMILES:
COc1ccc(c(OC)c1OC)-c1ccc(SC)c(=O)cc1
Structure:
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