Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50280338
Substrate
n/a
Meas. Tech.
ChEMBL_96619 (CHEMBL708177)
Ki
17500±n/a nM
Citation
 Groutas, WC; Brubaker, MJ; Venkataraman, R; Epp, JB; Houser-Archield, N; Chong, LS; McClenahan, JJ Potential mechanism-based inhibitors of proteolytic enzymes Bioorg Med Chem Lett 2:175-180 (1992)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50280338
Synonyms:
2-((S)-3-Amino-5-methyl-2-oxo-hexyl)-isoindole-1,3-dione; hydrochloride | CHEMBL542119
Type:
Small organic molecule
Emp. Form.:
C15H18N2O3
Mol. Mass.:
274.315
SMILES:
CC(C)C[C@H](N)C(=O)CN1C(=O)c2ccccc2C1=O |r|
Structure:
Search PDB for entries with ligand similarity: