Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50280916
Substrate
n/a
Meas. Tech.
ChEBML_35288
IC50
15±n/a nM
Citation
 Wu, MT; Ikeler, TJ; Ashton, WT; Chang, RS; Lotti, VJ; Greenlee, WJ Synthesis and structure-activity relationships of a novel series of non-peptide AT2-selective angiotensin II receptor antagonists Bioorg Med Chem Lett 3:2023-2028 (1993)    Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50280916
Synonyms:
1N,1N,4N,4N-tetraphenyl-2-methylhexahydro-1,4-pyrazinedicarboxamide | CHEMBL291818
Type:
Small organic molecule
Emp. Form.:
C31H30N4O2
Mol. Mass.:
490.5955
SMILES:
CC1CN(CCN1C(=O)N(c1ccccc1)c1ccccc1)C(=O)N(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: