Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50281633
Substrate
n/a
Meas. Tech.
ChEBML_40184
Ki
3±n/a nM
Citation
 Horwell, DC; Howson, W; Ratcliffe, GS; Rees, DC The design of a dipeptide library for screening at peptide receptor sites Bioorg Med Chem Lett 3:799-802 (1993)    Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
47859.34
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-1 receptors in HEK 293 cells.
Residue:
428
Sequence:
MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ
  
Inhibitor
Name:
BDBM50281633
Synonyms:
3-[(R)-2-Amino-2-((S)-1-benzyl-2-carboxy-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid adamantan-2-yl ester | CHEMBL168182
Type:
Small organic molecule
Emp. Form.:
C33H39N3O5
Mol. Mass.:
557.6799
SMILES:
C[C@@](N)(Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)N[C@H](CC(O)=O)Cc1ccccc1 |wU:1.0,wD:29.33,1.1,TLB:12:13:10.11.16:17,9:10:17:13.19.14,THB:12:11:17:13.19.14,14:15:10:13.12.19,14:13:10:15.16.17,(17.69,-2.7,;17.7,-1.17,;16.35,-1.89,;17.77,.37,;16.46,1.21,;15.02,.67,;14.06,1.84,;12.71,1.11,;12.69,-.4,;11.41,1.9,;10.05,1.16,;8.75,1.95,;7.23,1.72,;7,.2,;5.91,-.89,;7.42,-.56,;7.56,.98,;8.77,-1.31,;9.89,-.23,;8.38,-.49,;14.9,3.15,;14.48,4.63,;15.58,5.71,;17.07,5.31,;17.47,3.85,;16.37,2.75,;19,-1.99,;18.93,-3.54,;20.38,-1.28,;21.66,-2.1,;23.03,-1.38,;24.32,-2.2,;25.69,-1.48,;24.26,-3.74,;21.65,-4.65,;22.94,-5.48,;24.3,-4.76,;25.6,-5.57,;25.55,-7.12,;24.18,-7.82,;22.87,-7.02,)|
Structure:
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