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Target
Neurotensin receptor type 1
Ligand
BDBM50281785
Substrate
n/a
Meas. Tech.
ChEMBL_144293 (CHEMBL754794)
Ki
0.100000±n/a nM
Citation
 Henry, JA; Horwell, DC; Meecham, KG; Rees, DC A structure-affinity study of the amino acid side-chains in neurotensin : N and C terminal deletions and Ala-scan Bioorg Med Chem Lett 3:949-952 (1993)    Article 
Target
Name:
Neurotensin receptor type 1
Synonyms:
NT-R-1 | NTR1_MOUSE | Neurotensin 1 | Neurotensin receptor 1 | Neurotensin receptor type 1 | Ntsr | Ntsr1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47237.04
Organism:
MOUSE
Description:
Neurotensin 1 NTSR1 MOUSE::A2ACT4
Residue:
424
Sequence:
MHLNSSVQQGAPSEPGAQPFPHPQFGLETMLLALSLSNGSGNSSESILEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQNRSADGQHPGGLVCTPTVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANKLTVMVHQAAEQGRGVCTVGTHNSLEHSTFNMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRRRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
  
Inhibitor
Name:
BDBM50281785
Synonyms:
(S)-2-{2-[(S)-2-{[(S)-1-((S)-2-{(S)-2-[((S)-1-Acetyl-pyrrolidine-2-carbonyl)-amino]-5-guanidino-pentanoylamino}-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-amino}-3-(4-hydroxy-phenyl)-1-oxo-propylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid | CHEMBL174771
Type:
Small organic molecule
Emp. Form.:
C45H73N13O10
Mol. Mass.:
956.1422
SMILES:
CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CC(C)C)C(O)=O
Structure:
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