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Target
Neurotensin receptor type 1
Ligand
BDBM50281809
Substrate
n/a
Meas. Tech.
ChEBML_144305
Ki
63±n/a nM
Citation
 Christos, TE; Arvanitis, A; Cain, GA; Johnson, AL; Pottorf, RS; Tam, S; Schmidt, WK Stable isosteres of neurotensin c-terminal pentapeptides derived by modification of the amide function Bioorg Med Chem Lett 3:1035-1040 (1993)    Article 
Target
Name:
Neurotensin receptor type 1
Synonyms:
NTR1_RAT | Neurotensin receptor 1 | Ntsr | Ntsr1
Type:
PROTEIN
Mol. Mass.:
47070.64
Organism:
Rattus norvegicus
Description:
ChEMBL_1466612
Residue:
424
Sequence:
MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
  
Inhibitor
Name:
BDBM50281809
Synonyms:
(S)-2-{(2S,3S)-2-[(S)-2-{[(S)-1-((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoyl)-pyrrolidine-2-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid | CHEMBL8857
Type:
Small organic molecule
Emp. Form.:
C37H60N6O9
Mol. Mass.:
732.9071
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Structure:
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