Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50282276
Substrate
n/a
Meas. Tech.
ChEMBL_35438 (CHEMBL643798)
IC50
0.31±n/a nM
Citation
 Mantlo, NB; Kim, D; Ondeyka, D; Chang, RS; Kivlighn, SD; Siegl, PK; Greenlee, WJ Imidazo[4,5-b]pyridine-based AT1 / AT2 angiotensin II receptor antagonists Bioorg Med Chem Lett 4:17-22 (1994)    Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50282276
Synonyms:
CHEMBL304947 | Pentanoic acid {2-butyl-3-[2'-(3-cyclopentyl-propionylsulfamoyl)-biphenyl-4-ylmethyl]-5-methyl-3H-imidazo[4,5-b]pyridin-6-yl}-amide
Type:
Small organic molecule
Emp. Form.:
C37H47N5O4S
Mol. Mass.:
657.865
SMILES:
CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(cc3)-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)c2nc1C
Structure:
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