Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50282961
Substrate
n/a
Meas. Tech.
ChEBML_201734
IC50
89±n/a nM
Citation
 Yevich, JP; Dextraze, P; Taylor, DP; Moon, SL Synthesis and evaluation of n-substituted 1-(5-fluoro-2-pyrimidinyl)piperazine derivatives as potential anti-ischemic agents Bioorg Med Chem Lett 4:1941-1946 (1994)    Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50282961
Synonyms:
5-Fluoro-2-{4-[3-(4-fluoro-phenoxy)-propyl]-piperazin-1-yl}-pyrimidine | CHEMBL300150
Type:
Small organic molecule
Emp. Form.:
C17H20F2N4O
Mol. Mass.:
334.3637
SMILES:
Fc1ccc(OCCCN2CCN(CC2)c2ncc(F)cn2)cc1
Structure:
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