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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50283137
Substrate
n/a
Meas. Tech.
ChEMBL_138805 (CHEMBL751540)
IC50
8±n/a nM
Citation
 Quimby, SJ; Shannon, HE; Bymaster, FP; Sauerberg, P; Olesen, PH; Sheardown, MJ; Suzdak, PD; Mitch, CH Synthesis and structure activity relationships of alkyl substituted analogues of the functional M1 selective muscarinic receptor agonist xanomeline Bioorg Med Chem Lett 4:2205-2210 (1994)    Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50283137
Synonyms:
5-(4-Butoxy-[1,2,5]thiadiazol-3-yl)-1,2-dimethyl-1,2,3,6-tetrahydro-pyridine | CHEMBL70670
Type:
Small organic molecule
Emp. Form.:
C13H21N3OS
Mol. Mass.:
267.39
SMILES:
CCCCOc1nsnc1C1=CCC(C)N(C)C1 |t:11|
Structure:
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