Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50283325
Substrate
n/a
Meas. Tech.
ChEBML_201298
Ki
28±n/a nM
Citation
 Christos, TE; Cain, GA; Johnson, AL; Schmidt, WK; Tam, SW Novel ether derivatives of alkyl piperidines as potential sigma / 5HT2 antipsychotic agents Bioorg Med Chem Lett 4:2347-2352 (1994)    Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50283325
Synonyms:
1-Benzyl-4-[(E)-3-(4-trifluoromethyl-phenyl)-allyloxymethyl]-piperidine | CHEMBL430444
Type:
Small organic molecule
Emp. Form.:
C23H26F3NO
Mol. Mass.:
389.4538
SMILES:
FC(F)(F)c1ccc(\C=C\COCC2CCN(Cc3ccccc3)CC2)cc1
Structure:
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