Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50283326
Substrate
n/a
Meas. Tech.
ChEBML_201298
Ki
22±n/a nM
Citation
 Christos, TE; Cain, GA; Johnson, AL; Schmidt, WK; Tam, SW Novel ether derivatives of alkyl piperidines as potential sigma / 5HT2 antipsychotic agents Bioorg Med Chem Lett 4:2347-2352 (1994)    Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50283326
Synonyms:
1-Benzyl-4-(3,3-diphenyl-allyloxymethyl)-piperidine | CHEMBL75860
Type:
Small organic molecule
Emp. Form.:
C28H31NO
Mol. Mass.:
397.5518
SMILES:
[#6](-[#8]-[#6]-[#6]-1-[#6]-[#6]-[#7](-[#6]-c2ccccc2)-[#6]-[#6]-1)\[#6]=[#6](/c1ccccc1)-c1ccccc1
Structure:
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