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Target
Type-1 angiotensin II receptor
Ligand
BDBM50283593
Substrate
n/a
Meas. Tech.
ChEMBL_36624 (CHEMBL652864)
IC50
20±n/a nM
Citation
 Thomas, AP; Roberts, DA; Thomason, DA The synthesis and biological activity of tetrahydroquinoline angiotensin II antagonists containing a substituted biphenyltetrazole group Bioorg Med Chem Lett 4:2615-2620 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_CAVPO | AT1 | Angiotensin II type-1 receptor
Type:
PROTEIN
Mol. Mass.:
41004.19
Organism:
Cavia porcellus
Description:
ChEMBL_36783
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
  
Inhibitor
Name:
BDBM50283593
Synonyms:
4-(2-Ethyl-5,6,7,8-tetrahydro-quinolin-4-yloxymethyl)-2'-(2H-tetrazol-5-yl)-biphenyl-2-carboxylic acid methyl ester | CHEMBL86858
Type:
Small organic molecule
Emp. Form.:
C27H27N5O3
Mol. Mass.:
469.535
SMILES:
CCc1cc(OCc2ccc(c(c2)C(=O)OC)-c2ccccc2-c2nnn[nH]2)c2CCCCc2n1
Structure:
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