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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50284322
Substrate
n/a
Meas. Tech.
ChEMBL_140107 (CHEMBL748288)
Kd
89±n/a nM
Citation
 Malaska, MJ; Fauq, AH; Kozikowski, AP; Aagaard, PJ; McKinney, M Chemical modification of ring c of himbacine: Discovery of a pharmacophoric element for M2-selectivity Bioorg Med Chem Lett 5:61-66 (1995)    Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50284322
Synonyms:
Acetic acid (1R,3S,3aR,4R,4aS,8aR,9aS)-4-[(E)-2-((2R,6S)-1,6-dimethyl-piperidin-2-yl)-vinyl]-3-methyl-dodecahydro-naphtho[2,3-c]furan-1-yl ester | CHEMBL160755
Type:
Small organic molecule
Emp. Form.:
C24H39NO3
Mol. Mass.:
389.5714
SMILES:
C[C@@H]1O[C@H](OC(C)=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](\C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12
Structure:
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