Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50284608
Substrate
n/a
Meas. Tech.
ChEMBL_58484 (CHEMBL670415)
Ki
4.20±n/a nM
Citation
 Kuroita, T; Ikebe, T; Murakami, S; Takehara, S; Kawakita, T N-(2-pyrrolidinylmethyl)benzoxazine-8-carboxamides exhibiting high affinities for All of D2, 5-HT1 A, and 5-HT2 receptors Bioorg Med Chem Lett 5:1245-1250 (1995)    Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50284608
Synonyms:
4-Methyl-6-methylsulfanyl-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid ((R)-1-benzyl-pyrrolidin-2-ylmethyl)-amide | CHEMBL278151
Type:
Small organic molecule
Emp. Form.:
C23H29N3O2S
Mol. Mass.:
411.56
SMILES:
CSc1cc2N(C)CCOc2c(c1)C(=O)NC[C@H]1CCCN1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: