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Target
Sterol O-acyltransferase 1
Ligand
BDBM50284874
Substrate
n/a
Meas. Tech.
ChEMBL_28006 (CHEMBL642889)
IC50
63±n/a nM
Citation
 Chiari, A; Fancelli, D; Lovisolo, PP; Radice, A; Savoia, L; Severino, D; Ghiselli, G Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor Bioorg Med Chem Lett 5:1581-1586 (1995)    Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT
Type:
Multi-pass membrane protein may form homo- or heterodimers.
Mol. Mass.:
64751.94
Organism:
Homo sapiens (Human)
Description:
P35610
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50284874
Synonyms:
1-(2,6-Diisopropyl-phenyl)-3-((4R,5R)-4,5-dimethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-urea | CHEMBL40685
Type:
Small organic molecule
Emp. Form.:
C25H34N2O3
Mol. Mass.:
410.5491
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(O[C@H](C)[C@@H](C)O1)c1ccccc1
Structure:
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