Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50284962
Substrate
n/a
Meas. Tech.
ChEBML_140184
Ki
37000±n/a nM
Citation
 Wu, ES; Mack, RA; Kover, A; Loch, JT; Mullen, G; Murray, RJ; Gordon, JC; Machulskis, AC; McCreedy, SA; Blosser, JC Synthesis and biological activity of enantiomers of a conformationally restricted muscarone analog Bioorg Med Chem Lett 5:1813-1818 (1995)    Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50284962
Synonyms:
(R)-2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one | CHEMBL50831
Type:
Small organic molecule
Emp. Form.:
C10H17NO2
Mol. Mass.:
183.2475
SMILES:
C[C@H]1OC2(CC1=O)CCN(C)CC2
Structure:
Search PDB for entries with ligand similarity: