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Target
Platelet-activating factor receptor
Ligand
BDBM50286203
Substrate
n/a
Meas. Tech.
ChEBML_164930
IC50
3±n/a nM
Citation
 Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J Enantiodifferentiation of dihydropyridine PAF antagonists Bioorg Med Chem Lett 5:3085-3090 (1995)    Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50286203
Synonyms:
4-(2-Chloro-phenyl)-6-methyl-2-[2-(2-methyl-benzoimidazol-1-yl)-ethoxymethyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester | CHEMBL104290
Type:
Small organic molecule
Emp. Form.:
C32H32ClN5O4
Mol. Mass.:
586.081
SMILES:
CCOC(=O)C1=C(COCCn2c(C)nc3ccccc23)N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1 |c:5,t:23|
Structure:
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