Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50287236
Substrate
n/a
Meas. Tech.
ChEBML_49903
IC50
720±n/a nM
Citation
 Kawanishi, Y; Ishihara, S; Tsushima, T; Seno, K; Miyagoshi, M; Hagishita, S; Ishikawa, M; Shima, N; Shimamura, M; Ishihara, Y Design, synthesis, and pharmacological evaluation of dual histamine H2 and gastrin receptor antagonists Bioorg Med Chem Lett 6:1421-1426 (1996)    Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCK-A receptor | CCK-AR | CCK1-R | CCKAR_MOUSE | Cckar | Cholecystokinin A receptor | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 receptor
Type:
PROTEIN
Mol. Mass.:
48454.29
Organism:
Mus musculus
Description:
ChEMBL_40042
Residue:
436
Sequence:
MDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSAVQILLYSFIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLIPGVVMVVAYGLISLELYQGIKFDASQKKSAKEKRLSSGGGGGGGSSSSRYEDSDGCYLQKSRPPRKLELQQLSTSSSGGRINRIRSSGSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPTGVRGEVGEEEDGRTIRASLSRYSYSHMSTSAPPH
  
Inhibitor
Name:
BDBM50287236
Synonyms:
CHEMBL286907 | N-[2-(2-Guanidino-thiazol-4-ylmethylsulfanyl)-ethyl]-4-{2-[2-oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetylamino}-butyramide
Type:
Small organic molecule
Emp. Form.:
C36H40N10O4S2
Mol. Mass.:
740.897
SMILES:
[#6]-c1cccc(-[#7]-[#6](=O)-[#7]-[#6]-2-[#7]=[#6](-c3ccccc3)-c3ccccc3-[#7](-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#16]-[#6]-c3csc(\[#7]=[#6](\[#7])-[#7])n3)-[#6]-2=O)c1 |t:11|
Structure:
Search PDB for entries with ligand similarity: