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Target
Endothelin-converting enzyme 1
Ligand
BDBM50287862
Substrate
n/a
Meas. Tech.
ChEBML_64372
IC50
55±n/a nM
Citation
 Deprez, P; Guillaume, J; Dumas, J; Vevert, JP Thiol inhibitors of endothelin-converting enzyme Bioorg Med Chem Lett 6:2317-2322 (1996)    Article 
Target
Name:
Endothelin-converting enzyme 1
Synonyms:
ECE1_RAT | ENDOTHELIN | Ece1 | Endothelin-converting enzyme 1 | Endothelin-converting enzyme 1 (ECE)
Type:
Protein
Mol. Mass.:
86126.89
Organism:
Rattus norvegicus (Rat)
Description:
P42893
Residue:
762
Sequence:
MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW
  
Inhibitor
Name:
BDBM50287862
Synonyms:
(S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-3-(4-thiophen-2-yl-phenyl)-propionic acid | CHEMBL310112
Type:
Small organic molecule
Emp. Form.:
C23H23NO3S2
Mol. Mass.:
425.564
SMILES:
OC(=O)[C@H](Cc1ccc(cc1)-c1cccs1)NC(=O)[C@@H](CS)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: